View Google Scholar Profile for Dr. Galas

New: Tetrad Detection Software for Yeast Genetics

February 26, 2019

In many eukaryotes, including the yeasts Saccharomyces cerevisiae, it is possible to recover all four of the haploid products of a single meiosis, tetrads. These tetrads can be characterized genetically and phenotypically. Tetrad analysis is a powerful technique that is routinely used to make associations between genetic variation and phenotype, uncover gene-gene interactions, and identify non-reciprocal meiotic recombination events (e.g. gene conversions).

Selected Major Publications for David Galas, PhD

Branscomb, E. W. and Galas, D. J., “Progressive Decrease in Protein Synthesis Accuracy Induced by Streptomycin in E. coli,” Nature, 254:161-163 (1975). (reprinted in Benchmark Papers in Genetics Series, Genes, Proteins and Cellular Aging, ed. R. Holliday, van Nostrand Reinhold Co., New York, (1976).

Galas, D. J. and Schmitz, A., “DNAase Footprinting: A Simple Method for the Detection of Protein-DNA Binding Specificity,” Nucleic Acids Res., 5:3157-3170 (1978).

2021 Publications from the Galas Lab

Niinistö, S., Erlund, I., Lee, HS. et al. Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity. Sci Rep, 11, 3627; (2021).

Kunert-Graf, J., Sakhanenko, N.A., Galas, D.J. “Optimized Permutation Testing for Information Theoretic Measures of Multi-Gene Interactions”, BMC Bioinformatics, 7;22(1):180. doi: 10.1186/s12859-021-04107-6 (2021).

Lusardi, T.A., Sandau, U.S., Sakhanenko, N.A., Baker, S.C.B., Wiedrick, J.T., Lapidus, J.A., Raskind, M.A., Li, G., Peskind, E.R., Galas, D.J., Quinn, J.F., Saugstad, J.A. “Cerebrospinal Fluid MicroRNA Changes in Cognitively Normal Veterans With a History of Deployment-Associated Mild Traumatic Brain Injury”, Front Neurosci, 9;15:720778. doi: 10.3389/fnins.2021.720778. PMID: 34580583; PMCID: PMC8463659 (eCollection, 2021).

2020 Publications from the Galas Lab

Kunert-Graf, J., Sakhanenko, N.A., Galas, D.J. “Partial Information Decomposition and the Information Delta: A Geometric Unification Disentangling Non-Pairwise Information”, Entropy, 22(12), 1333;, (2020).

Uechi, L., Jalali, M., Wilbur, J.D., French, J.L., Jumbe, N.L., Meaney, M.J., Gluckman, P.D., Kamani, N., Sakhanenko, N.A., Galas, D.J. “Complex genetic dependencies among growth and neurological phenotypes in healthy children: towards deciphering developmental mechanisms”, PLoS One, 15(12): e0242684. (2020).

Galas, D.J., Kunert-Graf, J., Uechi, L., Sakhanenko, N.A. “Towards an information theory of quantitative genetics”, J Comp Biol, 28(0), 1-33. DOI: 10.1089/cmb.2020.0032 (2020).

2019 Publications from the Galas Lab

James Michael Kunert-Graf, Kristian Eschenburg, David Galas, J. Nathan Kutz, Swati Rane, Bingni Wen Brunton, “Extracting Reproducible Time-Resolved Resting State Networks using Dynamic Mode Decomposition”, Frontiers In Computational Neuroscience, 13:75. doi: 10.3389/fncom.2019.00075. eCollection 2019 (October 2019)

Paula M Godoy, Andrea J Barczak, Peter DeHoff, Srimeenakshi Srinivasan, Alton Etheridge, David Galas, Saumya Das, David J Erle, Louise Laurent, MD/PhD, “Comparison of reproducibility, accuracy, sensitivity, and specificity of miRNA quantification platforms”, Cell Reports, 29(12), 4212-4222.e5 (December 2019)

Sakhanenko, Cromie, Dudley, Galas, “Computational Inference Software for Tetrad Assembly from Randomly Arrayed Yeast Colonies”, G3: GENES, GENOMES, GENETICS Early online May 20, 2019; (May 2019)

Maria D. Giraldez, Ryan M. Spengler, Alton Etheridge, Annika J. Goicochea , Missy Tuck, Sung Won Choi, David J. Galas, Muneesh Tewari, “Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma”, The EMBO Journal (2019)e101695; May 3, 2019;  doi 10.15252/embj.2019101695 (May 2019)

Vikas Ghai, Taek-Kyun Kim, Alton Etheridge, Trine Nielsen, Torben Hansen, Oluf Pedersen, David Galas and Kai Wang, “Extracellular vesicle encapsulated microRNAs in patients with type 2 diabetes are affected by metformin treatment”, J. Clin. Med. 2019, 8, 617; doi:10.3390/jcm8050617 (May 2019)

Laurent, L. et al., “The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research”. Cell, 177(2):231-242 (April 2019)

Oscar D. Murillo, William Thistlethwaite, Joel Rozowsky, …, Matthew E. Roth, Mark B. Gerstein, Aleksandar Milosavljevic, “exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids”, Cell, 177, 463–477 4, 2019)

Uechi, L., Galas, D.J., Sakhanenko, N.A., “Multivariate analysis of data sets with missing values: an information theory-based reliability function”, J Comp Biol, 26(2), 152-171; (February 2019).

Sakhanenko, N.A., Galas, D.J., “Symmetries among multivariate information measures explored using Möbius operators”, Entropy, 21(1), 88; (January 2019).

2018 Publications from the Galas Lab

Etheridge, A., Wang, K., Baxter, D., Galas, D.J., “Optimized protocol for preparation of small RNA NGS libraries from biofluids”, Chapter: Methods in Molecular Biology (2018).

Heintz-Buschart, A., Yusuf, D., Kayen, A., Etheridge, A., Fritz, J., May, P., de Beaufort, C., Upadhyaya, B., Ghosal, A., Galas, D.J., Wilmes, P., “Small RNA profiling of low biomass samples: identification and removal of contaminants”, BMC Biology, 16:52 (2018).

2017 Publications from the Galas Lab

Patra, B., Kon, Y., Yadav, G., Sevold, A.W., Frumkin, J.P., Vallabhajosyula, R.R., Hintze, A., Østman, B., Schossau, J., Bhan, A., Marzolf, B., Tamashiro, J.K., Kaur, A., Baliga, N.S., Grayhack, E.J., Adami, C., Galas, D.J., Raval, A., Phizicky, E.M., Ray, A., “A genome-wide dosage suppressor network reveals genomic robustness”, Nucl Acids Res, 9;45(1):255-270. doi: 10.1093/nar/gkw1148 (2017).

Kunert-Graf, J., Sakhanenko, N.A., Galas, D.J. “Complexity and Vulnerability Analysis of the C. elegans Gap Junction Connectome”, Entropy: Complexity, 19(3), 104; doi:10.3390/e19030104 (2017).

“Your gift helps make today’s potential tomorrow’s healthier reality. Research is the key.”

William Hutchinson, MD
PNRI Founder

“If our society continues to support basic research on how living organisms function, it is likely that my great grandchildren will be spared the agony of losing family members to most types of cancer.”

Paul Boyer, Nobel Prize winner

“To raise new questions, new possibilities, to regard old problems from a new angle, requires creative imagination and marks real advance in science.”

Albert Einstein

“I believe in innovations and that the way you get innovation is you fund research and you learn the basic facts.”

Bill Gates

Support our innovative genetic research. Become a donor today.