Publications
2022 Publications from the Hagopian Lab
Ng K, Stavropoulos H, Anand V, Veijola R, Toppari J, Maziarz M, Lundgren M, Waugh K, Frohnert BI, Martin F, Hagopian W, Achenbach P; T1DI Study Group. Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children. Diabetes Care 2022 Jan 1;45(1):160-168. doi: 10.2337/dc21-0878.PMID: 34758977
Ghalwash M, Koski E, Veijola R, Toppari J, Hagopian W, Rewers M, Anand V. Simulating Screening for Risk of Childhood Diabetes: The Collaborative Open Outcomes tooL (COOL). AMIA Annu Symp Proc. 2022 Feb 21;2021:516-525. eCollection 2021.PMID: 35308967
Jacobsen LM, Vehik K, Veijola R, Warncke K, Toppari J, Steck AK, Gesualdo P, Akolkar B, Lundgren M, Hagopian WA, She JX, Rewers M, Ziegler AG, Krischer JP, Larsson HE, Haller MJ; TEDDY Study Group. Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2022 Mar 1;45(3):624-633. doi: 10.2337/dc21-0422.PMID: 35043162
Törn C, Liu X, Onengut-Gumuscu S, Counts KM, Moreno JL, Remedios CL, Chen WM, LeFaive J, Butterworth MD, Akolkar B, Krischer JP, Lernmark Å, Rewers M, She JX, Toppari J, Ziegler AG, Ratan A, Smith AV, Hagopian WA, Rich SS, Parikh HM; TEDDY Study Group. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022 Mar 16;12(1):4516. doi: 10.1038/s41598-022-08058-7.PMID: 35296692.
Oram RA, Sharp SA, Pihoker C, Ferrat L, Imperatore G, Williams A, Redondo MJ, Wagenknecht L, Dolan LM, Lawrence JM, Weedon MN, D’Agostino R, Hagopian WA, Divers J, Dabelea D. Utility of Diabetes Type-Specific Genetic Risk Scores for the Classification of Diabetes Type Among Multiethnic Youth. Diabetes Care. 2022 Mar 21:dc202872. doi: 10.2337/dc20-2872. Online ahead of print. PMID: 35312757
Kwon BC, Anand V, Achenbach P, Dunne JL, Hagopian W, Hu J, Koski E, Lernmark Å, Lundgren M, Ng K, Toppari J, Veijola R, Frohnert BI; T1DI Study Group. Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories. Nat Commun. 2022 Mar 21;13(1):1514. doi: 10.1038/s41467-022-28909-1.PMID: 35314671.
Sims EK, Besser REJ, Dayan C, Geno Rasmussen C, Greenbaum C, Griffin KJ, Hagopian W, Knip M, Long AE, Martin F, Mathieu C, Rewers M, Steck AK, Wentworth JM, Rich SS, Kordonouri O, Ziegler AG, Herold KC; NIDDK Type 1 Diabetes TrialNet Study Group. Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective. Diabetes. 2022 Apr 1;71(4):610-623. doi: 10.2337/dbi20-0054.PMID: 35316839
Segerstad EMHA, Liu X, Uusitalo U, Agardh D, Aronsson CA; TEDDY Study Group. Sources of dietary gluten in the first two years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: TEDDY study. Am J Clin Nutr. 2022 Apr 8:nqac086. doi: 10.1093/ajcn/nqac086. Online ahead of print. PMID: 35394004
Wyatt RC, Hagopian WA, Roep BO, Patel KA, Resnick B, Dobbs R, Hudson M; EXE-T1D Consortium, De Franco E, Ellard S, Flanagan SE, Hattersley AT, Oram RA, Johnson MB. Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes. Diabetologia. 2022 Apr 30. doi: 10.1007/s00125-022-05697-3. Online ahead of print.
Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA, Rich SS. Type 1 Diabetes in Diverse Ancestries and Use of Genetic Risk Scores. Lancet Diabetes and Endocrinology 2022. In press.
Ghalwash M, Dunne JL, Lundgren M, Rewers M, Ziegler A-G, Anand V, Toppari J, Veijola R, Hagopian W and the T1DI Study Group.Two-Age Islet Autoantibody Screening for Childhood Type 1 Diabetes. Lancet Diabetes and Endocrinology 2022. In press.
2019 Publications from the Hagopian Lab
Shapiro MR, Wasserfall CH, McGrail SM, Posgai AL, Bacher R, Muir A, Haller MJ, Schatz DA, Wesley J, Herrath M, Hagopian WA, Speake C, Atkinson MA, Brusko TM. Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis. Diabetes 2019 in press.(December 2019)
Li Q, Parikh H, Butterworth MD, Lernmark Å, Hagopian WA, Rewers M, She J, Toppari J, Ziegler AG, Akolkar B, Fiehn O, Fan S, Krischer JP, TEDDY Study Group. Longitudinal metabolome-wide signals in children developing islet autoantibodies in The Environ-mental Determinants of Diabetes in the Young (TEDDY) study. Diabetes 2019 in press.(December 2019)
Liu X, Vehik K, Huang Y, Larsson H, Toppari J, Ziegler AG, She JX, Rewers M, Hagopian WA, Akolkar B, Krischer J. Distinct growth phases in early life are associated with the risk of type 1 diabetes: The TEDDY Study. Diabetes Care 2019 in press.(December 2019)
Vehik K, Lynch KF, Wong MC, Tian X, Ross MC, Gibbs RA, Ajami NJ, Petrosino JF, Rewers M, Toppari J, Ziegler AG, She JX, Lernmark A, Akolkar B, Hagopian WA, Schatz DA, Krischer JP, Hyöty H, Lloyd RE; TEDDY Study Group. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes. Nat Med. 2019 Dec;25(12):1865-1872. doi: 10.1038/s41591-019-0667-0. Epub 2019 Dec 2. PMID: 31792456 (December 2019)
Mattila M, Erlund I, Lee H, Niinistö S, Uusitalo U, Aronsson CA, Hummel S, Parikh H, Rich S, Hagopian WA, Toppari J, Lernmark Å, Ziegler A, Rewers M, Krischer J, Norris J M, Virtanen SM, TEDDY Study Group. Plasma ascorbic acid (vitamin C) and the risk of islet autoimmunity and type 1 diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY) Study 2019 Diabetologia in press.(November 2019)
Lindfors K, Lin J, Lee HS, Hyöty H, Nykter M, Kurppa K, Liu E, Koletzko S, Rewers M, Hagopian WA, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Petrosino JF, Lloyd RE, Agardh D, TEDDY Study Group. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2019 Nov 19. pii: gutjnl-2019-319809. doi: 10.1136/gutjnl-2019-319809.(November 2019)
Johnson R, Vanderlinden L, Kechris K, Uusitalo U, Fiehn O, Sontag M, Crume T, Beyerlein B, Lernmark A, Toppari J, Ziegler A, She J, Hagopian W, Rewers M, Akolkar B, Krischer J, Virtanen S, Norris J, TEDDY Study Group. Metabolite-related dietary patterns and the development of islet autoimmunity. Sci Rep. 2019 9(1):14819. doi: 10.1038/s41598-019-51251-4.(October 2019)
Andrén Aronsson C, Lee HS, Hård Af Segerstad EM, Uusitalo U, Yang J, Koletzko S, Liu E, Kurppa K, Bingley PJ, Toppari J, Ziegler AG, She JX, Hagopian WA, Rewers M, Akolkar B, Krischer JP, Virtanen SM, Norris JM, Agardh D; TEDDY Study Group. Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk. JAMA 2019 Aug 13. PMID: 31408136 (August 2019)
Uusitalo U, Andren AC, Liu X, Skidmore J, Winkler C, Rewers MJ, Hagopian WA, She JX, Toppari J, Ziegler AG, Akolkar B, Norris JM, Virtanen SM, Krischer JP, Agardh D; Kurppa K, Yang J, Liu E, TEDDY Study Group. Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk. Nutrients. 2019 Aug 2;11(8). pii: E1790. doi: 10.3390/nu11081790. (August 2019)
Krischer JP, Liu X, Vehik K, Akolkar B, Hagopian WA, Rewers M, She JX, Toppari J, Ziegler AG, Lernmark Å; TEDDY Study Group. Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report. Diabetes Care. 2019 Jun; 42(6):1051-1060. PMID: 30967432. (June 2019)
Jacobsen LM, Larsson HE, Tamura RN, Vehik K, Clasen J, et al. Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children. Pediatr Diabetes. 2019 May;20(3):263-270. PubMed PMID: 30628751; NIHMSID: NIHMS1008925; PubMed Central PMCID: PMC6456374. (May 2019)
Perdigoto AL, Preston-Hurlburt P, Clark P, Long SA, Linsley PS, et al. Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis. Diabetologia. 2019 Apr;62(4):655-664. PubMed PMID: 30569273; NIHMSID: NIHMS1517070; PubMed Central PMCID: PMC6402971. (April 2019)
Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, et al. Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families. Diabetes. 2019 Apr;68(4):847-857. PubMed PMID: 30655385; PubMed Central PMCID: PMC6425872. (April 2019)
Silvis K, Aronsson CA, Liu X, Uusitalo U, Yang J, et al. Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study. Pediatr Diabetes. 2019 Feb;20(1):86-92. PubMed PMID: 30411443; NIHMSID: NIHMS999537; PubMed Central PMCID: PMC6341488. (February 2019)
Sharp SA, Rich SS, Wood AR, Jones SE, Beaumont RN, et al. Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis. Diabetes Care. 2019 Feb;42(2):200-207. PubMed PMID: 30655379; PubMed Central PMCID: PMC6341291. (February 2019)
Endesfelder D, Zu Castell W, Bonifacio E, Rewers M, Hagopian WA, et al. Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children. Diabetes. 2019 Jan;68(1):119-130. PubMed PMID: 30305370; PubMed Central PMCID: PMC6302536. (Januaray 2019)
2018 and Older Publications from the Hagopian Lab
Salami F, Lee HS, Freyhult E, Elding Larsson H, Lernmark Å, et al. Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes. Diabetes. 2018 Nov;67(11):2329-2336. PubMed PMID: 30104249; PubMed Central PMCID: PMC6198343.
Vatanen T, Franzosa EA, Schwager R, Tripathi S, Arthur TD, et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature. 2018 Oct;562(7728):589-594. PubMed PMID: 30356183; NIHMSID: NIHMS1506068; PubMed Central PMCID: PMC6296767.
Stewart CJ, Ajami NJ, O’Brien JL, Hutchinson DS, Smith DP, et al. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature. 2018 Oct;562(7728):583-588. PubMed PMID: 30356187; NIHMSID: NIHMS1006388; PubMed Central PMCID: PMC6415775.
Rewers M, Hyöty H, Lernmark Å, Hagopian W, She JX, et al. The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update. Curr Diab Rep. 2018 Oct 23;18(12):136. PubMed PMID: 30353256; NIHMSID: NIHMS1006423; PubMed Central PMCID: PMC6415767.
Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, et al. Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study. J Med Genet. 2018 Oct 4;PubMed PMID: 30287597.
Stanfill BA, Nakayasu ES, Bramer LM, Thompson AM, Ansong CK, et al. Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data. Mol Cell Proteomics. 2018 Sep;17(9):1824-1836. PubMed PMID: 29666158; PubMed Central PMCID: PMC6126382.
Smith LB, Liu X, Johnson SB, Tamura R, Elding Larsson H, et al. Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful?. Pediatr Diabetes. 2018 Aug;19(5):1025-1033. PubMed PMID: 29577538; NIHMSID: NIHMS958369; PubMed Central PMCID: PMC6030424.
Sharp SA, Weedon MN, Hagopian WA, Oram RA. Clinical and research uses of genetic risk scores in type 1 diabetes. Curr Opin Genet Dev. 2018 Jun;50:96-102. PubMed PMID: 29702327; NIHMSID: NIHMS963794; PubMed Central PMCID: PMC6089633.
Sharma A, Liu X, Hadley D, Hagopian W, Chen WM, et al. Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort. J Autoimmun. 2018 May;89:90-100. PubMed PMID: 29310926; NIHMSID: NIHMS932806; PubMed Central PMCID: PMC5902429.
Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, et al. Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children. PLoS Med. 2018 Apr;15(4):e1002548. PubMed PMID: 29614081; PubMed Central PMCID: PMC5882115.
Koletzko S, Lee HS, Beyerlein A, Aronsson CA, Hummel M, et al. Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study. J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):417-424. PubMed PMID: 28753178; NIHMSID: NIHMS891624; PubMed Central PMCID: PMC5787038.
Uusitalo U, Lee HS, Andrén Aronsson C, Vehik K, Yang J, et al. Early Infant Diet and Islet Autoimmunity in the TEDDY Study. Diabetes Care. 2018 Mar;41(3):522-530. PubMed PMID: 29343517; PubMed Central PMCID: PMC5829968.
Lynch KF, Lee HS, Törn C, Vehik K, Krischer JP, et al. Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies. J Autoimmun. 2018 Jan;86:93-103. PubMed PMID: 28941965; NIHMSID: NIHMS907744; PubMed Central PMCID: PMC5747989.
Elding Larsson H, Lynch KF, Lönnrot M, Haller MJ, Lernmark Å, et al. Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children. Diabetologia. 2018 Jan;61(1):193-202. PubMed PMID: 28990147; NIHMSID: NIHMS928111; PubMed Central PMCID: PMC5774660.
Norris JM, Lee HS, Frederiksen B, Erlund I, Uusitalo U, et al. Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity. Diabetes. 2018 Jan;67(1):146-154. PubMed PMID: 29061729; PubMed Central PMCID: PMC5741144.
Lönnrot M, Lynch KF, Elding Larsson H, Lernmark Å, Rewers MJ, et al. Correction to: Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study. Diabetologia. 2018 Jan;61(1):254. PubMed PMID: 29080005.
Steck AK, Larsson HE, Liu X, Veijola R, Toppari J, et al. Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls. Pediatr Diabetes. 2017 Dec;18(8):794-802. PubMed PMID: 28127835; NIHMSID: NIHMS862374; PubMed Central PMCID: PMC5529265.
Krischer JP, Liu X, Lernmark Å, Hagopian WA, Rewers MJ, et al. The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report. Diabetes. 2017 Dec;66(12):3122-3129. PubMed PMID: 28903990; PubMed Central PMCID: PMC5697938.
Kemppainen KM, Vehik K, Lynch KF, Larsson HE, Canepa RJ, et al. Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity. JAMA Pediatr. 2017 Dec 1;171(12):1217-1225. PubMed PMID: 29052687; NIHMSID: NIHMS918349; PubMed Central PMCID: PMC5716863.
Köhler M, Beyerlein A, Vehik K, Greven S, Umlauf N, et al. Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study. Acta Diabetol. 2017 Nov;54(11):1009-1017. PubMed PMID: 28856522; NIHMSID: NIHMS903081; PubMed Central PMCID: PMC5645259.
Hagopian W, Lee HS, Liu E, Rewers M, She JX, et al. Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity. Pediatrics. 2017 Nov;140(5)PubMed PMID: 29018046; NIHMSID: NIHMS918343; PubMed Central PMCID: PMC5654393.
Lönnrot M, Lynch KF, Elding Larsson H, Lernmark Å, Rewers MJ, et al. Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study. Diabetologia. 2017 Oct;60(10):1931-1940. PubMed PMID: 28770319; NIHMSID: NIHMS918340; PubMed Central PMCID: PMC5697762.
Krischer JP, Lynch KF, Lernmark Å, Hagopian WA, Rewers MJ, et al. Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study. Diabetes Care. 2017 Sep;40(9):1194-1202. PubMed PMID: 28646072; PubMed Central PMCID: PMC5566280.
Lundgren M, Steed LJ, Tamura R, Jonsdottir B, Gesualdo P, et al. Analgesic antipyretic use among young children in the TEDDY study: no association with islet autoimmunity. BMC Pediatr. 2017 May 16;17(1):127. PubMed PMID: 28511706; PubMed Central PMCID: PMC5434629.
Haghighi M, Johnson SB, Qian X, Lynch KF, Vehik K, et al. Corrigendum: A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Sci Rep. 2017 May 2;7:39723. PubMed PMID: 28462922; PubMed Central PMCID: PMC5411889.
Kemppainen KM, Lynch KF, Liu E, Lönnrot M, Simell V, et al. Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life. Clin Gastroenterol Hepatol. 2017 May;15(5):694-702.e5. PubMed PMID: 27840181; NIHMSID: NIHMS829397; PubMed Central PMCID: PMC5576726.
Yang J, Tamura RN, Aronsson CA, Uusitalo UM, Lernmark Å, et al. Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Br J Nutr. 2017 Feb;117(3):466-472. PubMed PMID: 28249640; NIHMSID: NIHMS865261; PubMed Central PMCID: PMC5477643.
Hummel S, Beyerlein A, Tamura R, Uusitalo U, Andrén Aronsson C, et al. First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Diabetes Care. 2017 Mar;40(3):398-404. PubMed PMID: 28096222; PubMed Central PMCID: PMC5319477.
Vehik K, Lynch KF, Schatz DA, Akolkar B, Hagopian W, et al. Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study. Diabetes Care. 2016 Sep;39(9):1535-42. PubMed PMID: 27311490; PubMed Central PMCID: PMC5001144.
Haghighi M, Johnson SB, Qian X, Lynch KF, Vehik K, et al. A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Sci Rep. 2016 Aug 26;6:30828. PubMed PMID: 27561809; PubMed Central PMCID: PMC5000469.
Elding Larsson H, Vehik K, Haller MJ, Liu X, Akolkar B, et al. Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study. Diabetes. 2016 Jul;65(7):1988-95. PubMed PMID: 26993064; PubMed Central PMCID: PMC4915577.
Törn C, Liu X, Hagopian W, Lernmark Å, Simell O, et al. Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. Sci Rep. 2016 Jun 16;6:27887. PubMed PMID: 27306948; PubMed Central PMCID: PMC4910045.
Yang J, Lynch KF, Uusitalo UM, Foterek K, Hummel S, et al. Factors associated with longitudinal food record compliance in a paediatric cohort study. Public Health Nutr. 2016 Apr;19(5):804-13. PubMed PMID: 26088478; NIHMSID: NIHMS708550; PubMed Central PMCID: PMC4684805.
Luo S, Lin J, Xie Z, Xiang Y, Zheng P, et al. HLA Genetic Discrepancy Between Latent Autoimmune Diabetes in Adults and Type 1 Diabetes: LADA China Study No 6. J Clin Endocrinol Metab. 2016 Apr;101(4):1693-700. PubMed PMID: 26866570.
Sharma A, Liu X, Hadley D, Hagopian W, Liu E, et al. Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort. PLoS One. 2016;11(3):e0152476. PubMed PMID: 27015091; PubMed Central PMCID: PMC4807782.
Andrén Aronsson C, Lee HS, Koletzko S, Uusitalo U, Yang J, et al. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol. 2016 Mar;14(3):403-409.e3. PubMed PMID: 26453955; NIHMSID: NIHMS729001; PubMed Central PMCID: PMC4897964.
Cabrera SM, Chen YG, Hagopian WA, Hessner MJ. Blood-based signatures in type 1 diabetes. Diabetologia. 2016 Mar;59(3):414-25. PubMed PMID: 26699650; NIHMSID: NIHMS747515; PubMed Central PMCID: PMC4744128.
Uusitalo U, Liu X, Yang J, Aronsson CA, Hummel S, et al. Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA Pediatr. 2016 Jan;170(1):20-8. PubMed PMID: 26552054; NIHMSID: NIHMS752422; PubMed Central PMCID: PMC4803028.
Lernmark B, Lynch K, Baxter J, Roth R, Simell T, et al. Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing. J Diabetes Res. 2016;2016:2720650. PubMed PMID: 26682228; PubMed Central PMCID: PMC4670659.
Maziarz M, Hagopian W, Palmer JP, Sanjeevi CB, Kockum I, et al. Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies. Genes Immun. 2015 Dec;16(8):541-51. PubMed PMID: 26513234; NIHMSID: NIHMS719384; PubMed Central PMCID: PMC4670274.
Mellati M, Eaton KD, Brooks-Worrell BM, Hagopian WA, Martins R, et al. Anti-PD-1 and Anti-PDL-1 Monoclonal Antibodies Causing Type 1 Diabetes. Diabetes Care. 2015 Sep;38(9):e137-8. PubMed PMID: 26116720.
Beyerlein A, Liu X, Uusitalo UM, Harsunen M, Norris JM, et al. Dietary intake of soluble fiber and risk of islet autoimmunity by 5 y of age: results from the TEDDY study. Am J Clin Nutr. 2015 Aug;102(2):345-52. PubMed PMID: 26156735; PubMed Central PMCID: PMC4515865.
Roth R, Lynch K, Lernmark B, Baxter J, Simell T, et al. Maternal anxiety about a child’s diabetes risk in the TEDDY study: the potential role of life stress, postpartum depression, and risk perception. Pediatr Diabetes. 2015 Jun;16(4):287-98. PubMed PMID: 25082392; NIHMSID: NIHMS598722; PubMed Central PMCID: PMC4312746.
Hadley D, Hagopian W, Liu E, She JX, Simell O, et al. HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study. Am J Gastroenterol. 2015 Jun;110(6):915-20. PubMed PMID: 26010309; NIHMSID: NIHMS700300; PubMed Central PMCID: PMC4487515.
Törn C, Hadley D, Lee HS, Hagopian W, Lernmark Å, et al. Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. Diabetes. 2015 May;64(5):1818-29. PubMed PMID: 25422107; PubMed Central PMCID: PMC4407865.
Krischer JP, Lynch KF, Schatz DA, Ilonen J, Lernmark Å, et al. The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study. Diabetologia. 2015 May;58(5):980-7. PubMed PMID: 25660258; NIHMSID: NIHMS662473; PubMed Central PMCID: PMC4393776.
Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, et al. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 2015 May;38(5):808-13. PubMed PMID: 25665818; PubMed Central PMCID: PMC4407751.
Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, et al. Clinical features of celiac disease: a prospective birth cohort. Pediatrics. 2015 Apr;135(4):627-34. PubMed PMID: 25733751; PubMed Central PMCID: PMC4379464.
Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet. 2015 Apr;47(4):381-6. PubMed PMID: 25751624; NIHMSID: NIHMS665498; PubMed Central PMCID: PMC4380767.
Lönnrot M, Lynch K, Larsson HE, Lernmark Å, Rewers M, et al. A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY. BMC Pediatr. 2015 Mar 20;15:24. PubMed PMID: 25884839; PubMed Central PMCID: PMC4377063.
Kemppainen KM, Ardissone AN, Davis-Richardson AG, Fagen JR, Gano KA, et al. Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes Care. 2015 Feb;38(2):329-32. PubMed PMID: 25519450; PubMed Central PMCID: PMC4302256.
Aronsson CA, Lee HS, Liu E, Uusitalo U, Hummel S, et al. Age at gluten introduction and risk of celiac disease. Pediatrics. 2015 Feb;135(2):239-45. PubMed PMID: 25601977; PubMed Central PMCID: PMC4306795.
Hummel S, Vehik K, Uusitalo U, McLeod W, Aronsson CA, et al. Infant feeding patterns in families with a diabetes history – observations from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study. Public Health Nutr. 2014 Dec;17(12):2853-62. PubMed PMID: 24477208; NIHMSID: NIHMS602404; PubMed Central PMCID: PMC4162845.
Yang J, Lernmark Å, Uusitalo UM, Lynch KF, Veijola R, et al. Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes. Int J Obes (Lond). 2014 Dec;38(12):1491-6. PubMed PMID: 24694666; NIHMSID: NIHMS578576; PubMed Central PMCID: PMC4185013.
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