2022 Publications from the Hagopian Lab

Ng K, Stavropoulos H, Anand V, Veijola R, Toppari J, Maziarz M, Lundgren M, Waugh K, Frohnert BI, Martin F, Hagopian W, Achenbach P; T1DI Study Group.  Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children. Diabetes Care 2022 Jan 1;45(1):160-168. doi: 10.2337/dc21-0878.PMID: 34758977

Ghalwash M, Koski E, Veijola R, Toppari J, Hagopian W, Rewers M, Anand V. Simulating Screening for Risk of Childhood Diabetes: The Collaborative Open Outcomes tooL (COOL). AMIA Annu Symp Proc. 2022 Feb 21;2021:516-525. eCollection 2021.PMID: 35308967

Jacobsen LM, Vehik K, Veijola R, Warncke K, Toppari J, Steck AK, Gesualdo P, Akolkar B, Lundgren M, Hagopian WA, She JX, Rewers M, Ziegler AG, Krischer JP, Larsson HE, Haller MJ; TEDDY Study Group.  Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2022 Mar 1;45(3):624-633. doi: 10.2337/dc21-0422.PMID: 35043162

Törn C, Liu X, Onengut-Gumuscu S, Counts KM, Moreno JL, Remedios CL, Chen WM, LeFaive J, Butterworth MD, Akolkar B, Krischer JP, Lernmark Å, Rewers M, She JX, Toppari J, Ziegler AG, Ratan A, Smith AV, Hagopian WA, Rich SS, Parikh HM; TEDDY Study Group. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022 Mar 16;12(1):4516. doi: 10.1038/s41598-022-08058-7.PMID: 35296692.

Oram RA, Sharp SA, Pihoker C, Ferrat L, Imperatore G, Williams A, Redondo MJ, Wagenknecht L, Dolan LM, Lawrence JM, Weedon MN, D’Agostino R, Hagopian WA, Divers J, Dabelea D.  Utility of Diabetes Type-Specific Genetic Risk Scores for the Classification of Diabetes Type Among Multiethnic Youth. Diabetes Care. 2022 Mar 21:dc202872. doi: 10.2337/dc20-2872. Online ahead of print. PMID: 35312757

Kwon BC, Anand V, Achenbach P, Dunne JL, Hagopian W, Hu J, Koski E, Lernmark Å, Lundgren M, Ng K, Toppari J, Veijola R, Frohnert BI; T1DI Study Group. Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories. Nat Commun. 2022 Mar 21;13(1):1514. doi: 10.1038/s41467-022-28909-1.PMID: 35314671.

Sims EK, Besser REJ, Dayan C, Geno Rasmussen C, Greenbaum C, Griffin KJ, Hagopian W, Knip M, Long AE, Martin F, Mathieu C, Rewers M, Steck AK, Wentworth JM, Rich SS, Kordonouri O, Ziegler AG, Herold KC; NIDDK Type 1 Diabetes TrialNet Study Group.  Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective. Diabetes. 2022 Apr 1;71(4):610-623. doi: 10.2337/dbi20-0054.PMID: 35316839

Segerstad EMHA, Liu X, Uusitalo U, Agardh D, Aronsson CA; TEDDY Study Group. Sources of dietary gluten in the first two years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: TEDDY study. Am J Clin Nutr. 2022 Apr 8:nqac086. doi: 10.1093/ajcn/nqac086. Online ahead of print. PMID: 35394004

Wyatt RC, Hagopian WA, Roep BO, Patel KA, Resnick B, Dobbs R, Hudson M; EXE-T1D Consortium, De Franco E, Ellard S, Flanagan SE, Hattersley AT, Oram RA, Johnson MB.  Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes. Diabetologia. 2022 Apr 30. doi: 10.1007/s00125-022-05697-3. Online ahead of print.

Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA, Rich SS.  Type 1 Diabetes in Diverse Ancestries and Use of Genetic Risk Scores. Lancet Diabetes and Endocrinology 2022. In press.

Ghalwash M, Dunne JL, Lundgren M, Rewers M, Ziegler A-G, Anand V, Toppari J, Veijola R, Hagopian W and the T1DI Study Group.Two-Age Islet Autoantibody Screening for Childhood Type 1 Diabetes. Lancet Diabetes and Endocrinology 2022. In press.

2019 Publications from the Hagopian Lab

Shapiro MR, Wasserfall CH, McGrail SM, Posgai AL, Bacher R, Muir A, Haller MJ, Schatz DA, Wesley J, Herrath M, Hagopian WA, Speake C, Atkinson MA, Brusko TM. Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis. Diabetes 2019 in press.(December 2019)

Li Q, Parikh H, Butterworth MD, Lernmark Å, Hagopian WA, Rewers M, She J, Toppari J, Ziegler AG, Akolkar B, Fiehn O, Fan S, Krischer JP, TEDDY Study Group.  Longitudinal metabolome-wide signals in children developing islet autoantibodies in The Environ-mental Determinants of Diabetes in the Young (TEDDY) study.  Diabetes 2019 in press.(December 2019)

Liu X, Vehik K, Huang Y, Larsson H, Toppari J, Ziegler AG, She JX, Rewers M, Hagopian WA, Akolkar B, Krischer J. Distinct growth phases in early life are associated with the risk of type 1 diabetes: The TEDDY Study.  Diabetes Care 2019 in press.(December 2019)

Vehik K, Lynch KF, Wong MC, Tian X, Ross MC, Gibbs RA, Ajami NJ, Petrosino JF, Rewers M, Toppari J, Ziegler AG, She JX, Lernmark A, Akolkar B, Hagopian WA, Schatz DA, Krischer JP, Hyöty H, Lloyd RE; TEDDY Study Group. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes. Nat Med. 2019 Dec;25(12):1865-1872. doi: 10.1038/s41591-019-0667-0. Epub 2019 Dec 2. PMID: 31792456 (December 2019)

2018 and Older Publications from the Hagopian Lab

Salami F, Lee HS, Freyhult E, Elding Larsson H, Lernmark Å, et al. Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes. Diabetes. 2018 Nov;67(11):2329-2336. PubMed PMID: 30104249; PubMed Central PMCID: PMC6198343.

Vatanen T, Franzosa EA, Schwager R, Tripathi S, Arthur TD, et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature. 2018 Oct;562(7728):589-594. PubMed PMID: 30356183; NIHMSID: NIHMS1506068; PubMed Central PMCID: PMC6296767.

Stewart CJ, Ajami NJ, O’Brien JL, Hutchinson DS, Smith DP, et al. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature. 2018 Oct;562(7728):583-588. PubMed PMID: 30356187; NIHMSID: NIHMS1006388; PubMed Central PMCID: PMC6415775.

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