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Publications from the Metzger Lab

Michnowska A, Hart SFM, Smolarz K, Hallmann A, Metzger MJ. Horizontal transmission of disseminated neoplasia in the widespread clam Macoma balthica from the Southern Baltic Sea. Mol Ecol2022 Apr 11;doi: 10.1111/mec.16464. [Epub ahead of print] PubMed PMID: 35403750.

Giersch RM, Hart SFM, Reddy SG, Yonemitsu MA, Orellana Rosales MJ, Korn M, Geleta BM, Countway PD, Fernández Robledo JA, Metzger MJ. Survival and Detection of Bivalve Transmissible Neoplasia from the Soft-Shell Clam Mya arenaria (MarBTN) in Seawater. Pathogens2022 Feb 23;11(3)doi: 10.3390/pathogens11030283. PubMed PMID: 35335607; PubMed Central PMCID: PMC8955499.

Hammel M, Simon A, Arbiol C, Villalba A, Burioli EAV, Pépin JF, Lamy JB, Benabdelmouna A, Bernard I, Houssin M, Charrière GM, Destoumieux-Garzon D, Welch JJ, Metzger MJ, Bierne N. Prevalence and polymorphism of a mussel transmissible cancer in Europe. Mol Ecol2022 Feb;31(3):736-751doi: 10.1111/mec.16052. Epub 2021 Jul 16. PubMed PMID: 34192383; PubMed Central PMCID: PMC8716645.

Keegan RM, Talbot LR, Chang YH, Metzger MJ, Dubnau J. Intercellular viral spread and intracellular transposition of Drosophila gypsy. PLoS Genet2021 Apr;17(4):e1009535doi: 10.1371/journal.pgen.1009535. eCollection 2021 Apr. PubMed PMID: 33886543; PubMed Central PMCID: PMC8096092.

Dujon AM, Aktipis A, Alix-Panabières C, Amend SR, Boddy AM, Brown JS, Capp JP, DeGregori J, Ewald P, Gatenby R, Gerlinger M, Giraudeau M, Hamede RK, Hansen E, Kareva I, Maley CC, Marusyk A, McGranahan N, Metzger MJ, Nedelcu AM, Noble R, Nunney L, Pienta KJ, Polyak K, Pujol P, Read AF, Roche B, Sebens S, Solary E, Staňková K, Swain Ewald H, Thomas F, Ujvari B. Identifying key questions in the ecology and evolution of cancer. Evol Appl2021 Apr;14(4):877-892doi: 10.1111/eva.13190. eCollection 2021 Apr. PubMed PMID: 33897809; PubMed Central PMCID: PMC8061275.

Yonemitsu MA, Giersch RM, Polo-Prieto M, Hammel M, Simon A, Cremonte F, Avilés FT, Merino-Véliz N, Burioli EA, Muttray AF, Sherry J, Reinisch C, Baldwin SA, Goff SP, Houssin M, Arriagada G, Vázquez N, Bierne N, Metzger MJ. A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe. Elife. 2019 Nov 5;8. doi: 10.7554/eLife.47788. PubMed PMID: 31686650; PubMed Central PMCID: PMC6831032.

Featured in:

Fernández Robledo JA, Yadavalli R, Allam B, Pales Espinosa E, Gerdol M, et al. From the raw bar to the bench: Bivalves as models for human health. Dev Comp Immunol. 2019 Mar;92:260-282. PubMed PMID: 30503358.

Metzger MJ, Paynter AN, Siddall ME, Goff SP. Horizontal transfer of retrotransposons between bivalves and other aquatic species of multiple phyla. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4227-E4235. PubMed PMID: 29669918; PubMed Central PMCID: PMC5939071.

Paynter AN, Metzger MJ, Sessa JA, Siddall ME. Evidence of horizontal transmission of the cancer-associated Steamer retrotransposon among ecological cohort bivalve species. Dis Aquat Organ. 2017 Apr 20;124(2):165-168. PubMed PMID: 28425429.

Metzger MJ, Goff SP. A Sixth Modality of Infectious Disease: Contagious Cancer from Devils to Clams and Beyond. PLoS Pathog. 2016 Oct;12(10):e1005904. PubMed PMID: 27788268; PubMed Central PMCID: PMC5082865.

Metzger MJ, Villalba A, Carballal MJ, Iglesias D, Sherry J, et al. Widespread transmission of independent cancer lineages within multiple bivalve species. Nature. 2016 Jun 30;534(7609):705-9. PubMed PMID: 27338791; NIHMSID: HHMIMS790109; PubMed Central PMCID: PMC4939143.

Griffin DO, Metzger M, Poeth K, Deng K, Dharsee A, et al. Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy. Open Forum Infect Dis. 2015 Dec;2(4):ofv147. PubMed PMID: 26566539; PubMed Central PMCID: PMC4630453.

Metzger MJ, Reinisch C, Sherry J, Goff SP. Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams. Cell. 2015 Apr 9;161(2):255-63. PubMed PMID: 25860608; NIHMSID: NIHMS668941; PubMed Central PMCID: PMC4393529.

Arriagada G, Metzger MJ, Muttray AF, Sherry J, Reinisch C, et al. Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14175-80. PubMed PMID: 25201971; PubMed Central PMCID: PMC4191779.

Metzger MJ, Certo MT. Design and analysis of site-specific single-strand nicking endonucleases for gene correction. Methods Mol Biol. 2014;1114:237-44. PubMed PMID: 24557907.

Metzger MJ, Stoddard BL, Monnat RJ Jr. PARP-mediated repair, homologous recombination, and back-up non-homologous end joining-like repair of single-strand nicks. DNA Repair (Amst). 2013 Jul;12(7):529-34. PubMed PMID: 23684799; NIHMSID: NIHMS472978; PubMed Central PMCID: PMC3683368.

Metzger MJ, Halperin AC, Manhart LE, Hawes SE. Association of maternal smoking during pregnancy with infant hospitalization and mortality due to infectious diseases. Pediatr Infect Dis J. 2013 Jan;32(1):e1-7. PubMed PMID: 22929173; NIHMSID: NIHMS409679; PubMed Central PMCID: PMC3588859.

Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, et al. Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space. Nucleic Acids Res. 2012 Jun;40(11):4954-64. PubMed PMID: 22334611; PubMed Central PMCID: PMC3367166.

Miller AD, Metzger MJ. APOBEC3-mediated hypermutation of retroviral vectors produced from some retrovirus packaging cell lines. Gene Ther. 2011 May;18(5):528-30. PubMed PMID: 21209627; NIHMSID: NIHMS264023; PubMed Central PMCID: PMC3085560.

Halbert CL, Metzger MJ, Lam SL, Miller AD. Capsid-expressing DNA in AAV vectors and its elimination by use of an oversize capsid gene for vector production. Gene Ther. 2011 Apr;18(4):411-7. PubMed PMID: 21160534; NIHMSID: NIHMS251226; PubMed Central PMCID: PMC3072450.

Metzger MJ, McConnell-Smith A, Stoddard BL, Miller AD. Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template. Nucleic Acids Res. 2011 Feb;39(3):926-35. PubMed PMID: 20876694; PubMed Central PMCID: PMC3035452.

Worobey M, Telfer P, Souquière S, Hunter M, Coleman CA, et al. Island biogeography reveals the deep history of SIV. Science. 2010 Sep 17;329(5998):1487. PubMed PMID: 20847261.

Metzger MJ, Miller AD. Acutely transforming retrovirus expressing Nras generated from HT-1080 fibrosarcoma cells infected with the human retrovirus XMRV. J Virol. 2010 Aug;84(15):7908-10. PubMed PMID: 20504941; PubMed Central PMCID: PMC2897646.

Metzger MJ, Holguin CJ, Mendoza R, Miller AD. The prostate cancer-associated human retrovirus XMRV lacks direct transforming activity but can induce low rates of transformation in cultured cells. J Virol. 2010 Feb;84(4):1874-80. PubMed PMID: 20007266; PubMed Central PMCID: PMC2812358.

Knouf EC, Metzger MJ, Mitchell PS, Arroyo JD, Chevillet JR, et al. Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells. J Virol. 2009 Jul;83(14):7353-6. PubMed PMID: 19403664; PubMed Central PMCID: PMC2704771.

Wootton SK, Metzger MJ, Hudkins KL, Alpers CE, York D, et al. Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV. Retrovirology. 2006 Dec 19;3:94. PubMed PMID: 17177996; PubMed Central PMCID: PMC1764900.

Pandrea I, Apetrei C, Dufour J, Dillon N, Barbercheck J, et al. Simian immunodeficiency virus SIVagmsab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts. J Virol. 2006 May;80(10):4858-67. PubMed PMID: 16641277; PubMed Central PMCID: PMC1472068.

Apetrei C, Becker J, Metzger M, Gautam R, Engle J, et al. Potential for HIV transmission through unsafe injections. AIDS. 2006 Apr 24;20(7):1074-6. PubMed PMID: 16603865.

Apetrei C, Kaur A, Lerche NW, Metzger M, Pandrea I, et al. Molecular epidemiology of simian immunodeficiency virus SIVsm in US primate centers unravels the origin of SIVmac and SIVstm. J Virol. 2005 Jul;79(14):8991-9005. PubMed PMID: 15994793; PubMed Central PMCID: PMC1168739.

Ylostalo J, Randall AC, Myers TA, Metzger M, Krogstad DJ, et al. Transcriptome profiles of host gene expression in a monkey model of human malaria. J Infect Dis. 2005 Feb 1;191(3):400-9. PubMed PMID: 15633100.

Traina-Dorge VL, Lorino R, Gormus BJ, Metzger M, Telfer P, et al. Molecular epidemiology of simian T-cell lymphotropic virus type 1 in wild and captive sooty mangabeys. J Virol. 2005 Feb;79(4):2541-8. PubMed PMID: 15681454; PubMed Central PMCID: PMC546543.

Apetrei C, Metzger MJ, Richardson D, Ling B, Telfer PT, et al. Detection and partial characterization of simian immunodeficiency virus SIVsm strains from bush meat samples from rural Sierra Leone. J Virol. 2005 Feb;79(4):2631-6. PubMed PMID: 15681464; PubMed Central PMCID: PMC546599.

Apetrei C, Gormus B, Pandrea I, Metzger M, ten Haaft P, et al. Direct inoculation of simian immunodeficiency virus from sooty mangabeys in black mangabeys (Lophocebus aterrimus): first evidence of AIDS in a heterologous African species and different pathologic outcomes of experimental infection. J Virol. 2004 Nov;78(21):11506-18. PubMed PMID: 15479792; PubMed Central PMCID: PMC523258.

Borchers MT, Ansay T, DeSalle R, Daugherty BL, Shen H, et al. In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration. J Leukoc Biol. 2002 Jun;71(6):1033-41. PubMed PMID: 12050190.

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