2019 Publications from the Nadeau Lab

Nadeau JH, Auwerx J. The virtuous cycle of human genetics and mouse models in drug discovery. Nat Rev Drug Discov. 2019 Apr;18(4):255-272. doi: 10.1038/s41573-018-0009-9. Review. PubMed PMID: 30679805. (April 2019)

Blanc V, Xie Y, Kennedy S, Riordan JD, Rubin DC, Madison BB, Mills JC, Nadeau JH, Davidson NO. Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver. RNA. 2019 Jan;25(1):70-81. doi: 10.1261/rna.068395.118. Epub 2018 Oct 11. PubMed PMID: 30309881; PubMed Central PMCID: PMC6298562. (January 2019)

2018 and Older Publications from the Nadeau Lab

Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, Roberts LR, Nadeau JH, Dupuy AJ, Keng VW, Largaespada DA. Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors. Cancer Res. 2017 Dec 1;77(23):6576-6588. doi: 10.1158/0008-5472.CAN-17-2281. Epub 2017 Oct 9. PubMed PMID: 28993411; PubMed Central PMCID: PMC5712258.

Nadeau JH. Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization. Genetics. 2017 Oct;207(2):369-387. doi: 10.1534/genetics.117.300109. Review. PubMed PMID: 28978771; PubMed Central PMCID: PMC5629312.

Riordan JD, Nadeau JH. From Peas to Disease: Modifier Genes, Network Resilience, and the Genetics of Health. Am J Hum Genet. 2017 Aug 3;101(2):177-191. doi: 10.1016/j.ajhg.2017.06.004. Review. PubMed PMID: 28777930; PubMed Central PMCID: PMC5544383.

Schlecht SH, Smith LM, Ramcharan MA, Bigelow EM, Nolan BT, Mathis NJ, Cathey A, Manley E Jr, Menon R, McEachin RC, Nadeau JH, Jepsen KJ. Canalization Leads to Similar Whole Bone Mechanical Function at Maturity in Two Inbred Strains of Mice. J Bone Miner Res. 2017 May;32(5):1002-1013. doi: 10.1002/jbmr.3093. Epub 2017 Feb 27. PubMed PMID: 28177139; PubMed Central PMCID: PMC5413428.

Baliga NS, Björkegren JL, Boeke JD, Boutros M, Crawford NP, Dudley AM, Farber CR, Jones A, Levey AI, Lusis AJ, Mak HC, Nadeau JH, Noyes MB, Petretto E, Seyfried NT, Steinmetz LM, Vonesch SC. The State of Systems Genetics in 2017. Cell Syst. 2017 Jan 25;4(1):7-15. doi: 10.1016/j.cels.2017.01.005. PubMed PMID: 28125793.

Doerner SK, Reis ES, Leung ES, Ko JS, Heaney JD, Berger NA, Lambris JD, Nadeau JH. High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity. Mol Cancer Res. 2016 Oct;14(10):953-965. doi: 10.1158/1541-7786.MCR-16-0153. Epub 2016 Aug 17. PubMed PMID: 27535705; PubMed Central PMCID: PMC5330314.

Buchner DA, Nadeau JH. Contrasting genetic architectures in different mouse reference populations used for studying complex traits. Genome Res. 2015 Jun;25(6):775-91. doi: 10.1101/gr.187450.114. Epub 2015 May 7. Review. PubMed PMID: 25953951; PubMed Central PMCID: PMC4448675.

Maywald RL, Doerner SK, Pastorelli L, De Salvo C, Benton SM, Dawson EP, Lanza DG, Berger NA, Markowitz SD, Lenz HJ, Nadeau JH, Pizarro TT, Heaney JD. IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2487-96. doi: 10.1073/pnas.1422445112. Epub 2015 Apr 27. PubMed PMID: 25918379; PubMed Central PMCID: PMC4434739.

Schneider JG, Nadeau JH. Turn up the heat: circulating serotonin tunes our internal heating system. Cell Metab. 2015 Feb 3;21(2):156-158. doi: 10.1016/j.cmet.2015.01.011. PubMed PMID: 25651169.

Spiezio SH, Amon LM, McMillen TS, Vick CM, Houston BA, Caldwell M, Ogimoto K, Morton GJ, Kirk EA, Schwartz MW, Nadeau JH, LeBoeuf RC. Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice. Mamm Genome. 2014 Dec;25(11-12):549-63. doi: 10.1007/s00335-014-9530-2. Epub 2014 Jul 8. PubMed PMID: 25001233; PubMed Central PMCID: PMC4241139.

Riordan JD, Nadeau JH. Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse. Mamm Genome. 2014 Oct;25(9-10):473-86. doi: 10.1007/s00335-014-9521-3. Epub 2014 May 7. Review. PubMed PMID: 24802098; PubMed Central PMCID: PMC4164843.

Smith LM, Bigelow EM, Nolan BT, Faillace ME, Nadeau JH, Jepsen KJ. Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice. Bone. 2014 Oct;67:130-8. doi: 10.1016/j.bone.2014.06.035. Epub 2014 Jul 6. PubMed PMID: 25003813; PubMed Central PMCID: PMC4413452.

Nakouzi GA, Nadeau JH. Does dietary folic acid supplementation in mouse NTD models affect neural tube development or gamete preference at fertilization?. BMC Genet. 2014 Aug 27;15:91. doi: 10.1186/s12863-014-0091-x. PubMed PMID: 25154628; PubMed Central PMCID: PMC4151023.

Dazard JE, Sandlers Y, Doerner SK, Berger NA, Brunengraber H. Metabolomics of ApcMin/+ mice genetically susceptible to intestinal cancer. BMC Syst Biol. 2014 Jun 23;8:72. doi: 10.1186/1752-0509-8-72. PubMed PMID: 24954394; PubMed Central PMCID: PMC4099115.

Blanc V, Park E, Schaefer S, Miller M, Lin Y, Kennedy S, Billing AM, Ben Hamidane H, Graumann J, Mortazavi A, Nadeau JH, Davidson NO. Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver. Genome Biol. 2014 Jun 19;15(6):R79. doi: 10.1186/gb-2014-15-6-r79. PubMed PMID: 24946870; PubMed Central PMCID: PMC4197816.

Xie F, von Dadelszen P, Nadeau J. CMV infection, TLR-2 and -4 expression, and cytokine profiles in early-onset preeclampsia with HELLP syndrome. Am J Reprod Immunol. 2014 Apr;71(4):379-86. doi: 10.1111/aji.12199. PubMed PMID: 24612145; PubMed Central PMCID: PMC3999254.

Cannon MV, Buchner DA, Hester J, Miller H, Sehayek E, Nadeau JH, Serre D. Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring. PLoS One. 2014;9(3):e90335. doi: 10.1371/journal.pone.0090335. eCollection 2014. PubMed PMID: 24594983; PubMed Central PMCID: PMC3940881.

Lehoczky JA, Thomas PE, Patrie KM, Owens KM, Villarreal LM, Galbraith K, Washburn J, Johnson CN, Gavino B, Borowsky AD, Millen KJ, Wakenight P, Law W, Van Keuren ML, Gavrilina G, Hughes ED, Saunders TL, Brihn L, Nadeau JH, Innis JW. A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice. PLoS Genet. 2013;9(12):e1003967. doi: 10.1371/journal.pgen.1003967. Epub 2013 Dec 5. PubMed PMID: 24339789; PubMed Central PMCID: PMC3854779.

DeSantis DA, Lee P, Doerner SK, Ko CW, Kawasoe JH, Hill-Baskin AE, Ernest SR, Bhargava P, Hur KY, Cresci GA, Pritchard MT, Lee CH, Nagy LE, Nadeau JH, Croniger CM. Genetic resistance to liver fibrosis on A/J mouse chromosome 17. Alcohol Clin Exp Res. 2013 Oct;37(10):1668-79. doi: 10.1111/acer.12157. Epub 2013 Jun 13. PubMed PMID: 23763294; PubMed Central PMCID: PMC3796136.

Zechel JL, Doerner SK, Lager A, Tesar PJ, Heaney JD, Nadeau JH. Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. BMC Genet. 2013 Jun 17;14:54. doi: 10.1186/1471-2156-14-54. PubMed PMID: 23773267; PubMed Central PMCID: PMC3693958.

Nelson VR, Heaney JD, Tesar PJ, Davidson NO, Nadeau JH. Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2766-73. doi: 10.1073/pnas.1207169109. Epub 2012 Aug 24. PubMed PMID: 22923694; PubMed Central PMCID: PMC3478648.

Nadeau JH, Forejt J, Takada T, Shiroishi T. Chromosome substitution strains: gene discovery, functional analysis, and systems studies. Mamm Genome. 2012 Oct;23(9-10):693-705. doi: 10.1007/s00335-012-9426-y. Epub 2012 Sep 8. Review. PubMed PMID: 22961226; PubMed Central PMCID: PMC3917716.

Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K. Inflammatory priming predisposes mice to age-related retinal degeneration. J Clin Invest. 2012 Aug;122(8):2989-3001. doi: 10.1172/JCI64427. Epub 2012 Jul 17. PubMed PMID: 22797304; PubMed Central PMCID: PMC3408755.

Buchner DA, Geisinger JM, Glazebrook PA, Morgan MG, Spiezio SH, Kaiyala KJ, Schwartz MW, Sakurai T, Furley AJ, Kunze DL, Croniger CM, Nadeau JH. The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity. Mamm Genome. 2012 Aug;23(7-8):431-42. doi: 10.1007/s00335-012-9400-8. Epub 2012 Jul 1. PubMed PMID: 22752552; PubMed Central PMCID: PMC3650838.

Spiezio SH, Takada T, Shiroishi T, Nadeau JH. Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice. BMC Genet. 2012 May 18;13:38. doi: 10.1186/1471-2156-13-38. PubMed PMID: 22606935; PubMed Central PMCID: PMC3406986.

Heaney JD, Anderson EL, Michelson MV, Zechel JL, Conrad PA, Page DC, Nadeau JH. Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice. Development. 2012 May;139(9):1577-86. doi: 10.1242/dev.076851. Epub 2012 Mar 21. PubMed PMID: 22438569; PubMed Central PMCID: PMC3317965.

Cowley AW Jr, Nadeau JH, Baccarelli A, Berecek K, Fornage M, Gibbons GH, Harrison DG, Liang M, Nathanielsz PW, O’Connor DT, Ordovas J, Peng W, Soares MB, Szyf M, Tolunay HE, Wood KC, Zhao K, Galis ZS. Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension. Hypertension. 2012 May;59(5):899-905. doi: 10.1161/HYPERTENSIONAHA.111.190116. Epub 2012 Mar 19. Review. PubMed PMID: 22431584; PubMed Central PMCID: PMC3885905.

Zechel JL, MacLennan GT, Heaney JD, Nadeau JH. Spontaneous metastasis in mouse models of testicular germ-cell tumours. Int J Androl. 2011 Aug;34(4 Pt 2):e278-87. doi: 10.1111/j.1365-2605.2011.01160.x. Epub 2011 Jun 9. PubMed PMID: 21651572; PubMed Central PMCID: PMC3979466.

Yazbek SN, Buchner DA, Geisinger JM, Burrage LC, Spiezio SH, Zentner GE, Hsieh CW, Scacheri PC, Croniger CM, Nadeau JH. Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis. Genome Res. 2011 Jul;21(7):1065-73. doi: 10.1101/gr.120741.111. Epub 2011 Apr 19. PubMed PMID: 21507882; PubMed Central PMCID: PMC3129249.

Buchner DA, Yazbek SN, Solinas P, Burrage LC, Morgan MG, Hoppel CL, Nadeau JH. Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance. Obesity (Silver Spring). 2011 May;19(5):917-24. doi: 10.1038/oby.2010.214. Epub 2010 Sep 30. PubMed PMID: 20885388; PubMed Central PMCID: PMC3749733.

Najm FJ, Chenoweth JG, Anderson PD, Nadeau JH, Redline RW, McKay RD, Tesar PJ. Isolation of epiblast stem cells from preimplantation mouse embryos. Cell Stem Cell. 2011 Mar 4;8(3):318-25. doi: 10.1016/j.stem.2011.01.016. PubMed PMID: 21362571; PubMed Central PMCID: PMC3073125.
Nadeau JH, Dudley AM. Genetics. Systems genetics. Science. 2011 Feb 25;331(6020):1015-6. doi: 10.1126/science.1203869. PubMed PMID: 21350153; PubMed Central PMCID: PMC4042627.

Cook MS, Munger SC, Nadeau JH, Capel B. Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Development. 2011 Jan;138(1):23-32. doi: 10.1242/dev.057000. Epub 2010 Nov 29. PubMed PMID: 21115610; PubMed Central PMCID: PMC2998163.
Nelson VR, Nadeau JH. Transgenerational genetic effects. Epigenomics. 2010 Dec;2(6):797-806. doi: 10.2217/epi.10.57. Review. PubMed PMID: 22122083; PubMed Central PMCID: PMC3720237.

Gray JD, Nakouzi G, Slowinska-Castaldo B, Dazard JE, Rao JS, Nadeau JH, Ross ME. Functional interactions between the LRP6 WNT co-receptor and folate supplementation. Hum Mol Genet. 2010 Dec 1;19(23):4560-72. doi: 10.1093/hmg/ddq384. Epub 2010 Sep 15. PubMed PMID: 20843827; PubMed Central PMCID: PMC2972692.

Yazbek SN, Spiezio SH, Nadeau JH, Buchner DA. Ancestral paternal genotype controls body weight and food intake for multiple generations. Hum Mol Genet. 2010 Nov 1;19(21):4134-44. doi: 10.1093/hmg/ddq332. Epub 2010 Aug 9. PubMed PMID: 20696673; PubMed Central PMCID: PMC2951864.

Zhu R, Heaney J, Nadeau JH, Ali S, Matin A. Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res. 2010 Sep 15;70(18):7264-72. doi: 10.1158/0008-5472.CAN-10-0820. Epub 2010 Aug 24. PubMed PMID: 20736371; PubMed Central PMCID: PMC2940986.

Sa Q, Hart E, Nadeau JH, Hoover-Plow JL. Mouse chromosome 17 candidate modifier genes for thrombosis. Mamm Genome. 2010 Aug;21(7-8):337-49. doi: 10.1007/s00335-010-9274-6. Epub 2010 Aug 11. PubMed PMID: 20700597; PubMed Central PMCID: PMC2923722.

Nelson VR, Spiezio SH, Nadeau JH. Transgenerational genetic effects of the paternal Y chromosome on daughters’ phenotypes. Epigenomics. 2010 Aug;2(4):513-21. doi: 10.2217/epi.10.26. PubMed PMID: 22121971; PubMed Central PMCID: PMC4045629.

Jepsen KJ, Courtland HW, Nadeau JH. Genetically determined phenotype covariation networks control bone strength. J Bone Miner Res. 2010 Jul;25(7):1581-93. doi: 10.1002/jbmr.41. PubMed PMID: 20200957; PubMed Central PMCID: PMC3154000.

Shao H, Sinasac DS, Burrage LC, Hodges CA, Supelak PJ, Palmert MR, Moreno C, Cowley AW Jr, Jacob HJ, Nadeau JH. Analyzing complex traits with congenic strains. Mamm Genome. 2010 Jun;21(5-6):276-86. doi: 10.1007/s00335-010-9267-5. Epub 2010 Jun 4. PubMed PMID: 20524000; PubMed Central PMCID: PMC3805105.

Eichler EE, Flint J, Gibson G, Kong A, Leal SM, Moore JH, Nadeau JH. Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet. 2010 Jun;11(6):446-50. doi: 10.1038/nrg2809. Review. PubMed PMID: 20479774; PubMed Central PMCID: PMC2942068.

Burrage LC, Baskin-Hill AE, Sinasac DS, Singer JB, Croniger CM, Kirby A, Kulbokas EJ, Daly MJ, Lander ES, Broman KW, Nadeau JH. Genetic resistance to diet-induced obesity in chromosome substitution strains of mice. Mamm Genome. 2010 Apr;21(3-4):115-29. doi: 10.1007/s00335-010-9247-9. Epub 2010 Feb 3. PubMed PMID: 20127486; PubMed Central PMCID: PMC3831885.

Dwyer-Nield LD, McQuillan J, Hill-Baskin A, Radcliffe RA, You M, Nadeau JH, Malkinson AM. Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains. Int J Cancer. 2010 Jan 1;126(1):125-32. doi: 10.1002/ijc.24743. PubMed PMID: 19609923; PubMed Central PMCID: PMC2783521.

Anderson PD, Nelson VR, Tesar PJ, Nadeau JH. Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation. Cancer Res. 2009 Dec 1;69(23):9112-7. doi: 10.1158/0008-5472.CAN-09-3342. Epub 2009 Nov 24. PubMed PMID: 19934337; PubMed Central PMCID: PMC3375044.

Leussis MP, Frayne ML, Saito M, Berry EM, Aldinger KA, Rockwell GN, Hammer RP Jr, Baskin-Hill AE, Singer JB, Nadeau JH, Sklar P, Petryshen TL. Genomic survey of prepulse inhibition in mouse chromosome substitution strains. Genes Brain Behav. 2009 Nov;8(8):806-16. doi: 10.1111/j.1601-183X.2009.00526.x. Epub 2009 Jul 21. PubMed PMID: 19694817; PubMed Central PMCID: PMC3746005.

Nadeau JH. Transgenerational genetic effects on phenotypic variation and disease risk. Hum Mol Genet. 2009 Oct 15;18(R2):R202-10. doi: 10.1093/hmg/ddp366. Review. PubMed PMID: 19808797; PubMed Central PMCID: PMC2758712.

Sudbery I, Stalker J, Simpson JT, Keane T, Rust AG, Hurles ME, Walter K, Lynch D, Teboul L, Brown SD, Li H, Ning Z, Nadeau JH, Croniger CM, Durbin R, Adams DJ. Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels. Genome Biol. 2009;10(10):R112. doi: 10.1186/gb-2009-10-10-r112. Epub 2009 Oct 13. PubMed PMID: 19825173; PubMed Central PMCID: PMC2784327.

Hill-Baskin AE, Markiewski MM, Buchner DA, Shao H, DeSantis D, Hsiao G, Subramaniam S, Berger NA, Croniger C, Lambris JD, Nadeau JH. Diet-induced hepatocellular carcinoma in genetically predisposed mice. Hum Mol Genet. 2009 Aug 15;18(16):2975-88. doi: 10.1093/hmg/ddp236. Epub 2009 May 19. PubMed PMID: 19454484; PubMed Central PMCID: PMC2714725.

Cook MS, Coveney D, Batchvarov I, Nadeau JH, Capel B. BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. Dev Biol. 2009 Apr 15;328(2):377-83. doi: 10.1016/j.ydbio.2009.01.041. Epub 2009 Feb 6. PubMed PMID: 19389346; PubMed Central PMCID: PMC2689365.

Anderson PD, Lam MY, Poirier C, Bishop CE, Nadeau JH. The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. Cancer Res. 2009 Apr 15;69(8):3614-8. doi: 10.1158/0008-5472.CAN-08-4881. Epub 2009 Apr 7. PubMed PMID: 19351821; PubMed Central PMCID: PMC3375048.

Heaney JD, Michelson MV, Youngren KK, Lam MY, Nadeau JH. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet. 2009 Apr 15;18(8):1395-404. doi: 10.1093/hmg/ddp045. Epub 2009 Jan 23. PubMed PMID: 19168544; PubMed Central PMCID: PMC2664146.

Tommasini SM, Hu B, Nadeau JH, Jepsen KJ. Phenotypic integration among trabecular and cortical bone traits establishes mechanical functionality of inbred mouse vertebrae. J Bone Miner Res. 2009 Apr;24(4):606-20. doi: 10.1359/jbmr.081224. PubMed PMID: 19063678; PubMed Central PMCID: PMC2659510.

Millward CA, Burrage LC, Shao H, Sinasac DS, Kawasoe JH, Hill-Baskin AE, Ernest SR, Gornicka A, Hsieh CW, Pisano S, Nadeau JH, Croniger CM. Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17. Mamm Genome. 2009 Feb;20(2):71-82. doi: 10.1007/s00335-008-9165-2. Epub 2009 Jan 10. PubMed PMID: 19137372; PubMed Central PMCID: PMC3831881.

Jepsen KJ, Hu B, Tommasini SM, Courtland HW, Price C, Cordova M, Nadeau JH. Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains. Mamm Genome. 2009 Jan;20(1):21-33. doi: 10.1007/s00335-008-9158-1. Epub 2008 Dec 5. PubMed PMID: 19082857; PubMed Central PMCID: PMC2650248.

Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O’Brien W, Courtland HW, Jepsen KJ, Kirby A, Kulbokas EJ, Daly MJ, Broman KW, Lander ES, Nadeau JH. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19910-4. doi: 10.1073/pnas.0810388105. Epub 2008 Dec 9. PubMed PMID: 19066216; PubMed Central PMCID: PMC2604967.

Courtland HW, Nasser P, Goldstone AB, Spevak L, Boskey AL, Jepsen KJ. Fourier transform infrared imaging microspectroscopy and tissue-level mechanical testing reveal intraspecies variation in mouse bone mineral and matrix composition. Calcif Tissue Int. 2008 Nov;83(5):342-53. doi: 10.1007/s00223-008-9176-8. Epub 2008 Oct 15. PubMed PMID: 18855037; PubMed Central PMCID: PMC2650490.

Kitami T, Rubio R, O’Brien W, Quackenbush J, Nadeau JH. Gene-environment interactions reveal a homeostatic role for cholesterol metabolism during dietary folate perturbation in mice. Physiol Genomics. 2008 Oct 8;35(2):182-90. doi: 10.1152/physiolgenomics.00294.2007. Epub 2008 Aug 12. PubMed PMID: 18697859; PubMed Central PMCID: PMC2575958.

Buchner DA, Burrage LC, Hill AE, Yazbek SN, O’Brien WE, Croniger CM, Nadeau JH. Resistance to diet-induced obesity in mice with a single substituted chromosome. Physiol Genomics. 2008 Sep 17;35(1):116-22. doi: 10.1152/physiolgenomics.00033.2008. Epub 2008 Jul 15. PubMed PMID: 18628339; PubMed Central PMCID: PMC2536825.

Sa Q, Hart E, Hill AE, Nadeau JH, Hoover-Plow JL. Quantitative trait locus analysis for hemostasis and thrombosis. Mamm Genome. 2008 Jun;19(6):406-12. doi: 10.1007/s00335-008-9122-0. Epub 2008 Sep 12. PubMed PMID: 18787898; PubMed Central PMCID: PMC3375051.

Gürkan E, Olszens KR, Nadeau JH, Loparo KA. Feature identification in circadian rhythms of mice strains using in vivo information. Mamm Genome. 2008 May;19(5):366-77. doi: 10.1007/s00335-008-9118-9. Epub 2008 Jul 1. PubMed PMID: 18592311; PubMed Central PMCID: PMC3375046.

Heaney JD, Lam MY, Michelson MV, Nadeau JH. Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice. Cancer Res. 2008 Jul 1;68(13):5193-7. doi: 10.1158/0008-5472.CAN-08-0779. PubMed PMID: 18593919; PubMed Central PMCID: PMC2562736.

Prows DR, Hafertepen AP, Winterberg AV, Gibbons WJ Jr, Wesselkamper SC, Singer JB, Hill AE, Nadeau JH, Leikauf GD. Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time. Am J Respir Cell Mol Biol. 2008 Jan;38(1):68-77. doi: 10.1165/rcmb.2006-0162OC. Epub 2007 Jul 26. PubMed PMID: 17656683; PubMed Central PMCID: PMC2176134.

Heaney JD, Nadeau JH. Testicular germ cell tumors in mice: new ways to study a genetically complex trait. Methods Mol Biol. 2008;450:211-31. doi: 10.1007/978-1-60327-214-8_15. PubMed PMID: 18370062.

Hammond S, Zhu R, Youngren KK, Lam J, Anderson P, Matin A. Chromosome X modulates incidence of testicular germ cell tumors in Ter mice. Mamm Genome. 2007 Dec;18(12):832-8. doi: 10.1007/s00335-007-9075-8. Epub 2007 Nov 30. PubMed PMID: 18049836; PubMed Central PMCID: PMC2647741.

Lam MY, Heaney JD, Youngren KK, Kawasoe JH, Nadeau JH. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet. 2007 Sep 15;16(18):2233-40. doi: 10.1093/hmg/ddm175. Epub 2007 Jul 5. PubMed PMID: 17616517.

Jepsen KJ, Hu B, Tommasini SM, Courtland HW, Price C, Terranova CJ, Nadeau JH. Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mamm Genome. 2007 Jul;18(6-7):492-507. doi: 10.1007/s00335-007-9017-5. Epub 2007 Jun 8. PubMed PMID: 17557179; PubMed Central PMCID: PMC1998883.

Strohl KP, Gallaugher L, Lynn A, Friedman L, Hill A, Singer JB, Lander ES, Nadeau J. Sleep-related epilepsy in the A/J mouse. Sleep. 2007 Feb;30(2):169-76. doi: 10.1093/sleep/30.2.169. PubMed PMID: 17326542.

Ernest S, Carter M, Shao H, Hosack A, Lerner N, Colmenares C, Rosenblatt DS, Pao YH, Ross ME, Nadeau JH. Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice. Hum Mol Genet. 2006 Dec 1;15(23):3387-93. doi: 10.1093/hmg/ddl415. Epub 2006 Oct 18. PubMed PMID: 17050573.

Hoover-Plow J, Shchurin A, Hart E, Sha J, Hill AE, Singer JB, Nadeau JH. Genetic background determines response to hemostasis and thrombosis. BMC Blood Disord. 2006 Oct 5;6:6. doi: 10.1186/1471-2326-6-6. PubMed PMID: 17022820; PubMed Central PMCID: PMC1617083.

Nadeau JH, Topol EJ. The genetics of health. Nat Genet. 2006 Oct;38(10):1095-8. doi: 10.1038/ng1006-1095. Review. PubMed PMID: 17006459.

Ozsoyoglu ZM, Ozsoyoglu G, Nadeau J. Genomic pathways database and biological data management. Anim Genet. 2006 Aug;37 Suppl 1:41-7. doi: 10.1111/j.1365-2052.2006.01477.x. PubMed PMID: 16887001.

Alkan C, Karakoç E, Nadeau JH, Sahinalp SC, Zhang K. RNA-RNA interaction prediction and antisense RNA target search. J Comput Biol. 2006 Mar;13(2):267-82. doi: 10.1089/cmb.2006.13.267. PubMed PMID: 16597239.

Nadeau JH, Lee C. Genetics: copies count. Nature. 2006 Feb 16;439(7078):798-9. doi: 10.1038/439798a. PubMed PMID: 16482142.
Hill AE, Lander ES, Nadeau JH. Chromosome substitution strains: a new way to study genetically complex traits. Methods Mol Med. 2006;128:153-72. doi: 10.1385/1-59745-159-2:153. PubMed PMID: 17071995.

Petryshen TL, Kirby A, Hammer RP Jr, Purcell S, O’Leary SB, Singer JB, Hill AE, Nadeau JH, Daly MJ, Sklar P. Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains. Genetics. 2005 Dec;171(4):1895-904. doi: 10.1534/genetics.105.045658. Epub 2005 Jul 5. PubMed PMID: 15998716; PubMed Central PMCID: PMC1456091.

Matin A, Nadeau JH. Search for testicular cancer gene hits dead-end. Cell Cycle. 2005 Sep;4(9):1136-8. doi: 10.4161/cc.4.9.1992. Epub 2005 Sep 6. Review. PubMed PMID: 16082220.

Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. 2005 May 19;435(7040):360-4. doi: 10.1038/nature03595. PubMed PMID: 15902260; PubMed Central PMCID: PMC1421521.

Ernest S, Hosack A, O’Brien WE, Rosenblatt DS, Nadeau JH. Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects. Physiol Genomics. 2005 May 11;21(3):404-10. doi: 10.1152/physiolgenomics.00199.2004. Epub 2005 Mar 1. PubMed PMID: 15741506.

Nadeau JH. Listening to genetic background noise. N Engl J Med. 2005 Apr 14;352(15):1598-9. doi: 10.1056/NEJMe058054. PubMed PMID: 15829543.

Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR. Interacting genetic loci cause airway hyperresponsiveness. Physiol Genomics. 2005 Mar 21;21(1):105-11. doi: 10.1152/physiolgenomics.00267.2004. Epub 2005 Jan 18. PubMed PMID: 15657107.

Singer JB, Hill AE, Nadeau JH, Lander ES. Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice. Genetics. 2005 Feb;169(2):855-62. doi: 10.1534/genetics.104.031492. Epub 2004 Sep 15. PubMed PMID: 15371360; PubMed Central PMCID: PMC1449086.

Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov;36(11):1133-7. doi: 10.1038/ng1104-1133. PubMed PMID: 15514660.

Poirier C, Qin Y, Adams CP, Anaya Y, Singer JB, Hill AE, Lander ES, Nadeau JH, Bishop CE. A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice. Genetics. 2004 Nov;168(3):1557-62. doi: 10.1534/genetics.104.032177. PubMed PMID: 15579706; PubMed Central PMCID: PMC1448764.

Krewson TD, Supelak PJ, Hill AE, Singer JB, Lander ES, Nadeau JH, Palmert MR. Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains. Endocrinology. 2004 Oct;145(10):4447-51. doi: 10.1210/en.2004-0543. Epub 2004 Jul 29. PubMed PMID: 15284200.

Kitami T, Ernest S, Gallaugher L, Friedman L, Frankel WN, Nadeau JH. Genetic and phenotypic analysis of seizure susceptibility in PL/J mice. Mamm Genome. 2004 Sep;15(9):698-703. doi: 10.1007/s00335-004-3007-7. PubMed PMID: 15389317.

Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ. Implementing large-scale ENU mutagenesis screens in North America. Genetica. 2004 Sep;122(1):51-64. Review. PubMed PMID: 15619961; PubMed Central PMCID: PMC3774779.

Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O’Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH. Genetic dissection of complex traits with chromosome substitution strains of mice. Science. 2004 Apr 16;304(5669):445-8. doi: 10.1126/science.1093139. Epub 2004 Mar 18. PubMed PMID: 15031436.

Lam MY, Youngren KK, Nadeau JH. Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice. Genetics. 2004 Feb;166(2):925-33. PubMed PMID: 15020477; PubMed Central PMCID: PMC1470739.

Ernest S, Carter M, Hosack A, Rosenblatt D, Ross E, Nadeau JH. Nutrigenes, functional genomics and systems biology. J Nutr. 2003 Dec;133(12):4267-8. doi: 10.1093/jn/133.12.4267. PubMed PMID: 14652385.

Shi Q, Hufeisen SJ, Wroblewski JT, Nadeau JH, Roth BL. L-homocysteine sulfinic acid and L-homocysteic acid stimulate phosphoinositide hydrolysis in rat cortical neurons. Ann N Y Acad Sci. 2003 Nov;1003:461-3. PubMed PMID: 14684489.

Sankoff D, Nadeau JH. Chromosome rearrangements in evolution: From gene order to genome sequence and back. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11188-9. doi: 10.1073/pnas.2035002100. Epub 2003 Sep 23. PubMed PMID: 14506293; PubMed Central PMCID: PMC208729.

Nadeau JH, Burrage LC, Restivo J, Pao YH, Churchill G, Hoit BD. Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations. Genome Res. 2003 Sep;13(9):2082-91. doi: 10.1101/gr.1186603. PubMed PMID: 12952877; PubMed Central PMCID: PMC403692.

Percec I, Thorvaldsen JL, Plenge RM, Krapp CJ, Nadeau JH, Willard HF, Bartolomei MS. An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse. Genetics. 2003 Aug;164(4):1481-94. PubMed PMID: 12930754; PubMed Central PMCID: PMC1462673.

Nadeau JH. Modifier genes and protective alleles in humans and mice. Curr Opin Genet Dev. 2003 Jun;13(3):290-5. Review. PubMed PMID: 12787792.
Krishnamurthy L, Nadeau J, Ozsoyoglu G, Ozsoyoglu M, Schaeffer G, Tasan M, Xu W. Pathways database system: an integrated system for biological pathways. Bioinformatics. 2003 May 22;19(8):930-7. doi: 10.1093/bioinformatics/btg113. PubMed PMID: 12761054.

Ozsoyoglu ZM, Nadeau JH, Ozsoyoglu G. Pathways database system. OMICS. 2003 Spring;7(1):123-5. doi: 10.1089/153623103322006779. PubMed PMID: 12831573.

Shi Q, Savage JE, Hufeisen SJ, Rauser L, Grajkowska E, Ernsberger P, Wroblewski JT, Nadeau JH, Roth BL. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42. doi: 10.1124/jpet.102.047092. PubMed PMID: 12649361.

Youngren KK, Nadeau JH, Matin A. Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modifications. Hum Mol Genet. 2003 Feb 15;12(4):389-98. doi: 10.1093/hmg/ddg036. PubMed PMID: 12566386.

Jepsen KJ, Akkus OJ, Majeska RJ, Nadeau JH. Hierarchical relationship between bone traits and mechanical properties in inbred mice. Mamm Genome. 2003 Feb;14(2):97-104. doi: 10.1007/s00335-002-3045-y. PubMed PMID: 12584605.

Lam MY, Nadeau JH. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS. 2003 Jan;111(1):184-90; discussion 191. Review. PubMed PMID: 12752260.

Nishimura I, Drake TA, Lusis AJ, Lyons KM, Nadeau JH, Zernik J. ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities. Crit Rev Oral Biol Med. 2003;14(5):320-30. Review. PubMed PMID: 14530301.

Glazier AM, Nadeau JH, Aitman TJ. Finding genes that underlie complex traits. Science. 2002 Dec 20;298(5602):2345-9. doi: 10.1126/science.1076641. Review. PubMed PMID: 12493905.

Nadeau JH. Single nucleotide polymorphisms: tackling complexity. Nature. 2002 Dec 5;420(6915):517-8. doi: 10.1038/420517a. PubMed PMID: 12466848.
Kitami T, Nadeau JH. Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication. Nat Genet. 2002 Sep;32(1):191-4. doi: 10.1038/ng945. Epub 2002 Aug 5. PubMed PMID: 12161750.

Erhart MA, Lekgothoane S, Grenier J, Nadeau JH. Pattern of segmental recombination in the distal inversion of mouse t haplotypes. Mamm Genome. 2002 Aug;13(8):438-44. doi: 10.1007/s00335-002-3012-7. PubMed PMID: 12226709.

Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science. 2002 May 31;296(5573):1661-71. doi: 10.1126/science.1069193. PubMed PMID: 12040188.

Percec I, Plenge RM, Nadeau JH, Bartolomei MS, Willard HF. Autosomal dominant mutations affecting X inactivation choice in the mouse. Science. 2002 May 10;296(5570):1136-9. doi: 10.1126/science.1070087. PubMed PMID: 12004136.

Hoit BD, Kiatchoosakun S, Restivo J, Kirkpatrick D, Olszens K, Shao H, Pao YH, Nadeau JH. Naturally occurring variation in cardiovascular traits among inbred mouse strains. Genomics. 2002 May;79(5):679-85. doi: 10.1006/geno.2002.6754. PubMed PMID: 11991717.

Ernest S, Christensen B, Gilfix BM, Mamer OA, Hosack A, Rodier M, Colmenares C, McGrath J, Bale A, Balling R, Sankoff D, Rosenblatt DS, Nadeau JH. Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mamm Genome. 2002 May;13(5):259-67. doi: 10.1007/s00335-001-3054-2. PubMed PMID: 12016514.

Han F, Subramanian S, Price ER, Nadeau J, Strohl KP. Periodic breathing in the mouse. J Appl Physiol (1985). 2002 Mar;92(3):1133-40. doi: 10.1152/japplphysiol.00785.2001. PubMed PMID: 11842050.

Matin A, Nadeau JH. Sensitized polygenic trait analysis. Trends Genet. 2001 Dec;17(12):727-31. Review. PubMed PMID: 11718927.

Jepsen KJ, Pennington DE, Lee YL, Warman M, Nadeau J. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J Bone Miner Res. 2001 Oct;16(10):1854-62. doi: 10.1359/jbmr.2001.16.10.1854. PubMed PMID: 11585350.

Robin NH, Nadeau JH. Disorganization in mice and humans. Am J Med Genet. 2001 Jul 15;101(4):334-8. PubMed PMID: 11471156.

Nadeau JH. Modifier genes in mice and humans. Nat Rev Genet. 2001 Mar;2(3):165-74. doi: 10.1038/35056009. Review. PubMed PMID: 11256068.

Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, Hrabe de Angelis M, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka A, Rinchik EM, Rossant J, Russell LB, Schimenti J, Shiroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W, Zimmer A. Sequence interpretation. Functional annotation of mouse genome sequences. Science. 2001 Feb 16;291(5507):1251-5. PubMed PMID: 11233449.

Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X. The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51. doi: 10.1126/science.1058040. PubMed PMID: 11181995.

Hoit BD, Nadeau JH. Phenotype-driven genetic approaches in mice: high-throughput phenotyping for discovering new models of cardiovascular disease. Trends Cardiovasc Med. 2001 Feb;11(2):82-9. Review. PubMed PMID: 11530297.

Jiang LI, Nadeau JH. 129/Sv mice–a model system for studying germ cell biology and testicular cancer. Mamm Genome. 2001 Feb;12(2):89-94. Review. PubMed PMID: 11210194.

Chadwick LH, McCandless SE, Silverman GL, Schwartz S, Westaway D, Nadeau JH. Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. Genomics. 2000 Nov 15;70(1):66-73. doi: 10.1006/geno.2000.6319. PubMed PMID: 11087663.

Nadeau JH, Frankel WN. The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs. Nat Genet. 2000 Aug;25(4):381-4. doi: 10.1038/78051. PubMed PMID: 10932178.

Nadeau JH. Muta-genetics or muta-genomics: the feasibility of large-scale mutagenesis and phenotyping programs. Mamm Genome. 2000 Jul;11(7):603-7. PubMed PMID: 10886031.

Plenge RM, Percec I, Nadeau JH, Willard HF. Expression-based assay of an X-linked gene to examine effects of the X-controlling element (Xce) locus. Mamm Genome. 2000 May;11(5):405-8. PubMed PMID: 10790543.

Nadeau JH, Singer JB, Matin A, Lander ES. Analysing complex genetic traits with chromosome substitution strains. Nat Genet. 2000 Mar;24(3):221-5. doi: 10.1038/73427. Review. PubMed PMID: 10700173.

Faiella A, Wernig M, Consalez GG, Hostick U, Hofmann C, Hustert E, Boncinelli E, Balling R, Nadeau JH. A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression. Hum Mol Genet. 2000 Jan 22;9(2):227-36. doi: 10.1093/hmg/9.2.227. PubMed PMID: 10607833.

Keri RA, Lozada KL, Abdul-Karim FW, Nadeau JH, Nilson JH. Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):383-7. doi: 10.1073/pnas.97.1.383. PubMed PMID: 10618427; PubMed Central PMCID: PMC26672.

Matin A, Collin GB, Asada Y, Varnum D, Nadeau JH. Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain. Nat Genet. 1999 Oct;23(2):237-40. doi: 10.1038/13874. PubMed PMID: 10508525.

Colvin JS, Feldman B, Nadeau JH, Goldfarb M, Ornitz DM. Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Dev Dyn. 1999 Sep;216(1):72-88. doi: 10.1002/(SICI)1097-0177(199909)216:1<72::AID-DVDY9>3.0.CO;2-9. PubMed PMID: 10474167.

Nadeau JH, Rubin E, Schimenti J. Note to the community. Mamm Genome. 1999 Jun;10(6):654. PubMed PMID: 10341107.

Nadeau JH. Rattus norvegicus and the Industrial Revolution. Nat Genet. 1999 May;22(1):3-4. doi: 10.1038/8703. PubMed PMID: 10319846.

Nadeau JH, Sankoff D. Counting on comparative maps. Trends Genet. 1998 Dec;14(12):495-501. Review. PubMed PMID: 9865155.

Beamer WG, Shultz KL, Tennent BJ, Nadeau JH, Churchill GA, Eicher EM. Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res. 1998 Aug 15;58(16):3694-9. PubMed PMID: 9721880.

Matin A, Collin GB, Asada Y, Varnum D, Martone DL, Nadeau JH. Simple sequence length polymorphisms (SSLPs) that distinguish MOLF/Ei and 129/Sv inbred strains of laboratory mice. Mamm Genome. 1998 Aug;9(8):668-70. doi: 10.1007/s003359900842. PubMed PMID: 9680390.

Nadeau JH, Dunn PJ. Genomic strategies for defining and dissecting developmental and physiological pathways. Curr Opin Genet Dev. 1998 Jun;8(3):311-5. Review. PubMed PMID: 9690993.

Nadeau JH, Sankoff D. The lengths of undiscovered conserved segments in comparative maps. Mamm Genome. 1998 Jun;9(6):491-5. PubMed PMID: 9585444.
King BL, Sirugo G, Nadeau JH, Hudson TJ, Kidd KK, Kacinski BM, Schalling M. Long CAG/CTG repeats in mice. Mamm Genome. 1998 May;9(5):392-3. PubMed PMID: 9545500.

Abbadi N, Nadeau JH. Encyclopedia of the mouse genome VII. Mouse chromosome 14. Mamm Genome. 1998;8 Spec No:S275-91. PubMed PMID: 9662631.
Matin A, Collin GB, Varnum DS, Nadeau JH. Testicular teratocarcinogenesis in mice–a review. APMIS. 1998 Jan;106(1):174-82. Review. PubMed PMID: 9524576.

Silver LM, Nadeau JH, Brown SDM, Eppig JT, Peters J. Mammalian Genome, Incorporating Mouse Genome. Mamm Genome. 1998 Jan;9(1):1. PubMed PMID: 9435276.

Robin NH, Abbadi N, McCandless SE, Nadeau JH. Disorganization in mice and humans and its relation to sporadic birth defects. Am J Med Genet. 1997 Dec 31;73(4):425-36. Review. PubMed PMID: 9415470.

Nadeau JH, Sankoff D. Comparable rates of gene loss and functional divergence after genome duplications early in vertebrate evolution. Genetics. 1997 Nov;147(3):1259-66. PubMed PMID: 9383068; PubMed Central PMCID: PMC1208249.

Ehrlich J, Sankoff D, Nadeau JH. Synteny conservation and chromosome rearrangements during mammalian evolution. Genetics. 1997 Sep;147(1):289-96. PubMed PMID: 9286688; PubMed Central PMCID: PMC1208112.

Threadgill DW, Yee D, Matin A, Nadeau JH, Magnuson T. Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mamm Genome. 1997 Jun;8(6):390-3. PubMed PMID: 9166580.

Threadgill DW, Matin A, Yee D, Carrasquillo MM, Henry KR, Rollins KG, Nadeau JH, Magnuson T. SSLPs to map genetic differences between the 129 inbred strains and closed-colony, random-bred CD-1 mice. Mamm Genome. 1997 Jun;8(6):441-2. PubMed PMID: 9166591.

DiDonato CJ, Chen XN, Noya D, Korenberg JR, Nadeau JH, Simard LR. Cloning, characterization, and copy number of the murine survival motor neuron gene: homolog of the spinal muscular atrophy-determining gene. Genome Res. 1997 Apr;7(4):339-52. PubMed PMID: 9110173.

DiDonato CJ, Nadeau JH, Simard LR. The mouse neuronal apoptosis inhibitory protein gene maps to a conserved syntenic region of mouse chromosome 13. Mamm Genome. 1997 Mar;8(3):222. PubMed PMID: 9069126.

Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet. 1997 Mar;15(3):289-92. doi: 10.1038/ng0397-289. PubMed PMID: 9054944.

Sankoff D, Ferretti V, Nadeau JH. Conserved segment identification. J Comput Biol. 1997 Winter;4(4):559-65. doi: 10.1089/cmb.1997.4.559. PubMed PMID: 9385546.

Nadeau JH, Sankoff D. Landmarks in the Rosetta Stone of mammalian comparative maps. Nat Genet. 1997 Jan;15(1):6-7. doi: 10.1038/ng0197-6. PubMed PMID: 8988158.

Abbadi N, Nadeau JH. Mouse chromosome 14. Mamm Genome. 1997;7 Spec No:S238-50. PubMed PMID: 9233397.

Eppig JJ, Wigglesworth K, Varnum DS, Nadeau JH. Genetic regulation of traits essential for spontaneous ovarian teratocarcinogenesis in strain LT/Sv mice: aberrant meiotic cell cycle, oocyte activation, and parthenogenetic development. Cancer Res. 1996 Nov 1;56(21):5047-54. PubMed PMID: 8895763.

Rozmahel R, Wilschanski M, Matin A, Plyte S, Oliver M, Auerbach W, Moore A, Forstner J, Durie P, Nadeau J, Bear C, Tsui LC. Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor. Nat Genet. 1996 Mar;12(3):280-7. doi: 10.1038/ng0396-280. PubMed PMID: 8589719.

Koop BF, Nadeau JH. Pufferfish and new paradigm for comparative genome analysis. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1363-5. doi: 10.1073/pnas.93.4.1363. PubMed PMID: 8643636; PubMed Central PMCID: PMC39942.

Collin GB, Asada Y, Varnum DS, Nadeau JH. DNA pooling as a quick method for finding candidate linkages in multigenic trait analysis: an example involving susceptibility to germ cell tumors. Mamm Genome. 1996 Jan;7(1):68-70. PubMed PMID: 8903734.

Nadeau JH. Encyclopedia of the mouse genome V. Mouse chromosome 14. Mamm Genome. 1996;6 Spec No:S245-55. PubMed PMID: 8800769.

Eppig JT, Nadeau JH. Comparative maps: the mammalian jigsaw puzzle. Curr Opin Genet Dev. 1995 Dec;5(6):709-16. Review. PubMed PMID: 8745068.

Helwig U, Imai K, Schmahl W, Thomas BE, Varnum DS, Nadeau JH, Balling R. Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice. Nat Genet. 1995 Sep;11(1):60-3. doi: 10.1038/ng0995-60. PubMed PMID: 7550316.

Segre JA, Nemhauser JL, Taylor BA, Nadeau JH, Lander ES. Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. Genomics. 1995 Aug 10;28(3):549-59. doi: 10.1006/geno.1995.1187. PubMed PMID: 7490093.

Mills KA, Mathews KD, Scherpbier-Heddema T, Schelper RL, Schmalzel R, Bailey HL, Nadeau JH, Buetow KH, Murray JC. Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80. PubMed PMID: 7613034.

Koizumi T, Hendel E, Lalley PA, Tchetgen MB, Nadeau JH. Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14. Mamm Genome. 1995 Apr;6(4):263-8. PubMed PMID: 7613031.

Nadeau JH, Grant PL, Mankala S, Reiner AH, Richardson JE, Eppig JT. A Rosetta stone of mammalian genetics. Nature. 1995 Jan 26;373(6512):363-5. doi: 10.1038/373363a0. PubMed PMID: 7830773.

Coucouvanis EC, Martin GR, Nadeau JH. Genetic approaches for studying programmed cell death during development of the laboratory mouse. Methods Cell Biol. 1995;46:387-440. Review. PubMed PMID: 7609658.

Kasahara M, Hayashi M, Yoshida MC, Nadeau JH, Fujimoto S, Ishibashi T. Mapping of acidic epididymal glycoprotein (Aeg) genes to mouse chromosome 17. Mamm Genome. 1995 Jan;6(1):52-4. PubMed PMID: 7719028.

Nadeau JH, Arbuckle LD, Skamene E. Genetic dissection of inflammatory responses. J Inflamm. 1995;45(1):27-48. Review. PubMed PMID: 7583351.

Asada Y, Nadeau JH. Fert is on mouse chromosome 11, not chromosome 17. Mamm Genome. 1994 Dec;5(12):830. PubMed PMID: 7894174.

Cheah YC, Nadeau JH, Pugh S, Paigen B. New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains. Mamm Genome. 1994 Dec;5(12):762-7. PubMed PMID: 7894156.

Wang S, Lapierre P, Robert MF, Nadeau JH, Mitchell GA. Hormone-sensitive lipase maps to proximal chromosome 7 in mice and is genetically distinct from the Ad and Tub loci. Genomics. 1994 Nov 15;24(2):416-7. doi: 10.1006/geno.1994.1646. PubMed PMID: 7698777.

Gurish MF, Johnson KR, Webster MJ, Stevens RL, Nadeau JH. Location of the mouse mast cell protease 7 gene (Mcpt7) to chromosome 17. Mamm Genome. 1994 Oct;5(10):656-7. PubMed PMID: 7849408.

Ringwald M, Baldock R, Bard J, Kaufman M, Eppig JT, Richardson JE, Nadeau JH, Davidson D. A database for mouse development. Science. 1994 Sep 30;265(5181):2033-4. PubMed PMID: 8091224.

Magenis RE, Smith L, Nadeau JH, Johnson KR, Mountjoy KG, Cone RD. Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Mamm Genome. 1994 Aug;5(8):503-8. PubMed PMID: 7949735.

Nasir J, Lin B, Bucan M, Koizumi T, Nadeau JH, Hayden MR. The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3. Genomics. 1994 Jul 1;22(1):198-201. doi: 10.1006/geno.1994.1361. PubMed PMID: 7959767.

Ko MS, Wang X, Horton JH, Hagen MD, Takahashi N, Maezaki Y, Nadeau JH. Genetic mapping of 40 cDNA clones on the mouse genome by PCR. Mamm Genome. 1994 Jun;5(6):349-55. PubMed PMID: 8043949.

Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MS, Thurston SJ, Birkenmeier EH. Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm Genome. 1994 May;5(5):253-74. PubMed PMID: 8075499.

Asada Y, Varnum DS, Frankel WN, Nadeau JH. A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18. Nat Genet. 1994 Apr;6(4):363-8. doi: 10.1038/ng0494-363. PubMed PMID: 8054975.

Lisitsyn NA, Segre JA, Kusumi K, Lisitsyn NM, Nadeau JH, Frankel WN, Wigler MH, Lander ES. Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nat Genet. 1994 Jan;6(1):57-63. doi: 10.1038/ng0194-57. PubMed PMID: 8136836.

Nadeau JH, McCarthy L, Cox R. Mouse chromosome 14. Mamm Genome. 1994;5 Spec No:S207-16. PubMed PMID: 7719007.

Robin NH, Adewale OO, McDonald-McGinn D, Nadeau JH, Zackai EH, Bućan M. Human malformations similar to those in the mouse mutation disorganization (Ds). Hum Genet. 1993 Nov;92(5):461-4. PubMed PMID: 8244336.

Copeland NG, Gilbert DJ, Jenkins NA, Nadeau JH, Eppig JT, Maltais LJ, Miller JC, Dietrich WF, Steen RG, Lincoln SE. Genome maps IV 1993. Wall chart. Science. 1993 Oct 1;262(5130):67-82. PubMed PMID: 8211131.

Goulding M, Sterrer S, Fleming J, Balling R, Nadeau J, Moore KJ, Brown SD, Steel KP, Gruss P. Analysis of the Pax-3 gene in the mouse mutant splotch. Genomics. 1993 Aug;17(2):355-63. doi: 10.1006/geno.1993.1332. PubMed PMID: 8406486.

Bućan M, Gatalica B, Nolan P, Chung A, Leroux A, Grossman MH, Nadeau JH, Emanuel BS, Budarf M. Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum Mol Genet. 1993 Aug;2(8):1245-52. doi: 10.1093/hmg/2.8.1245. PubMed PMID: 8401507.

Cone RD, Mountjoy KG, Robbins LS, Nadeau JH, Johnson KR, Roselli-Rehfuss L, Mortrud MT. Cloning and functional characterization of a family of receptors for the melanotropic peptides. Ann N Y Acad Sci. 1993 May 31;680:342-63. Review. PubMed PMID: 8390157.

Gurish MF, Nadeau JH, Johnson KR, McNeil HP, Grattan KM, Austen KF, Stevens RL. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14. J Biol Chem. 1993 May 25;268(15):11372-9. PubMed PMID: 8098710.

Crosby JL, Varnum DS, Nadeau JH. Two-hit model for sporadic congenital anomalies in mice with the disorganization mutation. Am J Hum Genet. 1993 May;52(5):866-74. PubMed PMID: 8488837; PubMed Central PMCID: PMC1682043.

Robbins LS, Nadeau JH, Johnson KR, Kelly MA, Roselli-Rehfuss L, Baack E, Mountjoy KG, Cone RD. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell. 1993 Mar 26;72(6):827-34. PubMed PMID: 8458079.

Wevrick R, Barker JE, Nadeau JH, Szpirer C, Buchwald M. Mapping of the murine and rat Facc genes and assessment of flexed-tail as a candidate mouse homolog of Fanconi anemia group C. Mamm Genome. 1993;4(8):440-4. PubMed PMID: 7690622.

Wang S, Nadeau JH, Duncan A, Robert MF, Fontaine G, Schappert K, Johnson KR, Zietkiewicz E, Hruz P, Miziorko H. 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL): cloning and characterization of a mouse liver HL cDNA and subchromosomal mapping of the human and mouse HL genes. Mamm Genome. 1993;4(7):382-7. PubMed PMID: 8102917.

Nadeau JH, McCarthy L, Cox R. Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 14. Mamm Genome. 1993;4 Spec No:S203-10. PubMed PMID: 8268675.

Candia AF, Hu J, Crosby J, Lalley PA, Noden D, Nadeau JH, Wright CV. Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36. PubMed PMID: 1363541.

Chapman VM, Nadeau JH. The mouse genome: an overview. Curr Opin Genet Dev. 1992 Jun;2(3):406-11. Review. PubMed PMID: 1504614.

Nadeau JH, Taylor BA. Lengths of chromosomal segments conserved since divergence of man and mouse. Proc Natl Acad Sci U S A. 1984 Feb;81(3):814-8. doi: 10.1073/pnas.81.3.814. PubMed PMID: 6583681; PubMed Central PMCID: PMC344928.

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